Corwin Hansch. The Pioneer of QSAR

In tribute to Corwin Hansch, father of QSAR

In this issue of Journal of Computer-Aided Molecular Design we pay tribute to Corwin Hansch, who died on May 8 at the age of 91. Professor Hansch (Corwin to almost everyone, at his insistence) was a giant in our field, the ‘father’ of QSAR, and the vanguard of rational drug design. Thanks to his long-time colleague and coworker, Cynthia Selassie, also of Pomona College, we are, with sadness, pu...

QSAR : Hansch Analysis and Related Approaches

From Hansch-Fujita Analysis to AFMoC: A Road to Structure-Based QSAR.

Since the pioneering effort of Hansch and Fujita, quantitative structure-activity relationships (QSAR) have proved valuable in optimizing lead structures. Enriching classical 3D-QSAR analysis, which exploits the three-dimensional structure of ligands, with structural information of the target has helped to improve the interpretability of the derived models and to increase their predictive power...

A Kinetic Basis for the Hansch Equation

The Hansch equation is a key mathematical relationship and a conceptual guiding principle (QSAR) in the practice of modern medicinal chemistry. Recent years have apparently witnessed a debate on the utility of QSAR, hence it seems opportune to explore its fundamental origins. The Hansch equation leads to a parabolic relationship between drug activity and hydrophobicity. Currently, this is expla...

the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)

cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...